Pre-cleanse, cleanse, and tone before applying the Vita-Peptide C-Quence Serum 2, follow with the Antioxidant Defence Creme. Alternatively mix the Antioxidant Defence Creme and the Vita-Peptide C-Quence Serum 2 in the palm of your hand before applying to face and neck. Apply both morning and evening. Use a minimum of 2 bottles before processing to the next level of the Vitamin A step-up system. Appropriate for all skin types, especially mature and sun-damaged. Not recommended for problematic skin.